Impact of spontaneous smoking cessation on sperm quality: case report

E. Prentki Santos, S. López-Costa, P. Chenlo, M. N. Pugliese, S. Curi, J. Ariagno, H. Repetto, M. Sardi, L. Palaoro & G. Mendeluk

Laboratory of Andrology and Male Fertility, Clinical Hospital, INFIBIOC, University of Buenos Aires, Argentina; Urology Division, Tobacco Cessation Program, Ramos Mejía Hospital, Government of the City of Buenos Aires, Argentina

We evaluated sperm quality after a 3-month smoking cessation programme by sperm analysis, objective sperm motility analysis, protein tyrosine phosphorylation in capacitating conditions and DNA fragmentation (TUNEL). Sperm analysis after smoking cessation revealed a distinctive improvement in sperm concentration, fast spermatozoa (‡35 lm/s), sperm vitality, percentage of spermatozoa recuperated after an enrichment technique and protein tyrosine phosphorylation. However, no changes were observed in the number of germinal cells in the ejaculate, sperm morphology and sperm DNA fragmentation. It is concluded that physicians should strongly advise their patients to quit smoking before undergoing medical treatment or assisted reproduction techniques to achieve pregnancy.

doi: 10.1111/j.1439-0272.2010.01089.x